Obstructive Lung Disease
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Study links isoflavone intake to reduced COPD morbidity
Mariah K. Jackson, PhD, RDN, LMNT, said that while the research does not establish causality, nutrition is generally a safe, well-tolerated, and cost-effective strategy to improve respiratory health.
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Large trial finds no advantage for balanced fluids over saline in pediatric sepsis
Investigators Fran Balamuth, MD, PhD, MSCE, and Scott L. Weiss, MD, MSCE, said the results support the use of either therapy for initial sepsis resuscitation in children.
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Study evaluates sleep efficiency change in patients with pediatric OSA following adenotonsillectomy
Pediatric pulmonologist Anne C. Coates, MD, said it may take longer to see a benefit from surgery in some populations, especially when nonrespiratory factors may be affecting sleep efficiency.
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Mucus plugging in severe asthma: Clinical significance and emerging therapeutic targets
As image-based markers become increasingly integrated into severe asthma phenotyping, the mucus plug score may evolve into a clinically actionable tool.
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DPP-1 inhibitors enter clinical practice
Sunjay R. Devarajan, MD, FCCP, and Anas Hadeh, MD, FCCP, said DPP-1 inhibitors are expected to become a new standard of care, with ongoing studies further defining their role in noncystic fibrosis bronchiectasis management.
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HFOV outperformed conventional ventilation for neonatal ARDS in trial
While the results need to be verified in larger, multicenter populations, new data show high-frequency oscillatory ventilation reduced the incidence of bronchopulmonary dysplasia in preterm infants.
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Biologic therapy for severe asthma: Time for precision, access, and accountability
Choosing the appropriate initial biologic and having the ability to implement timely changes in therapy, if needed, lead to improved patient-centered outcomes in severe asthma.
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Retrospective study confirms RSV, flu significantly increase hospitalization risk in pediatric patients
The study showed that children with comorbidities are at the highest risk, with a fivefold increase in severe outcomes.
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Rapid RSV testing may reduce antibiotic use in pediatric respiratory infections
Riccardo Boracchini, MSc, said the study provides some of the strongest evidence to date that rapid diagnostic testing can reduce antibiotic use outside the hospital setting.
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Rethinking pediatric home mechanical ventilation
Persistent disparities in caregiver burden, home nursing shortages, and access to resources highlight the need for standardized education, telemedicine integration, and national safety infrastructure.
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Triple therapy shows meaningful benefits in uncontrolled asthma
Alberto Papi, MD, FCCP, said recent data from the KALOS and LOGOS trials suggest triple therapy may address airflow limitation and exacerbation risk in a single inhaler.
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Umeclidinium-vilanterol shows modest but consistent advantage among LAMA-LABA options in symptomatic COPD
Investigator William B. Feldman, MD, PhD, MPH, said the findings raise important questions about whether inhalers in the same class are indeed therapeutically equivalent for patients with COPD.
