Critical Care Network
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Precision immunotherapy in sepsis: Beyond one size fits all
In an era of precision immunotherapy that targets specific pathways of the immune response based on measurable biomarkers, the development of rapid, multidimensional immune phenotyping tools is essential to translate precision sepsis care from concept to bedside.
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Rethinking vascular access in the ICU: The rise of peripheral vasopressors
Peripheral vasopressors are no longer an exception reserved for minutes before central access is obtained; they have become common practice nationwide.
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Impossible choices: Goal-concordant care in the ICU
Clinicians should approach discussions about goal-concordant care with curiosity, humility, and responsibility, for the benefit of both the patient and their family.
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Ventilatory management of immune checkpoint inhibitor pneumonitis
As immune checkpoint inhibitor use continues to expand, prospective data on phenotype-guided management and extracorporeal membrane oxygenation selection criteria are urgently needed.
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Navigating normotensive shock
Authors discuss the role normotensive shock plays in PE risk stratification according to new AHA guidelines on PE classification and management.
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When norepinephrine isn’t enough: Managing vasoplegic shock
Early recognition and structured escalation of therapy are essential in vasoplegic shock, as prompt restoration of vascular tone remains critical to reversing shock and improving patient outcomes.
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Beyond ‘doing everything’: Moral distress, burnout, and the emotional toll of ICU care
ICU burnout and morally distressing end-of-life care are intertwined, making improved end-of-life care both a patient imperative and a clinician necessity.
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Mechanical power as a target for lung protective ventilation
Mechanical power-based strategies aim to minimize unnecessary power delivery and reduce harm. Review how to measure and use this metric and what challenges it poses.
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Is there a ‘best’ vasopressor and inotrope combination for shock with RV failure?
Review unique pathophysiologic challenges of RV failure in shock and comparative data on vasopressors and inotropes.
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Post-intensive care syndrome: Beyond the ICU
As we shift from a survival-focused paradigm to one that embraces recovery and restoration, addressing PICS must become a routine component of ICU care.
