Pharmacology
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Third trial supports sotatercept to treat PAH
Guidelines expert James R. Klinger, MD, FCCP, said that while the evidence of efficacy is clear, more research is needed to address questions regarding the optimal duration of therapy and the potential for disease progression if therapy is stopped.
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Oseltamivir found to lower risk of flu-linked neuropsychiatric events in children
This study is the largest and most comprehensive US investigation of the drug and severe neuropsychiatric events, said author James Antoon, MD, PhD, MPH.
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Experts evaluate treatment of PAH in the sotatercept era
Zeenat Safdar, MD, FCCP, reviewed recent clinical trial data on the use of the activin-signaling inhibitor sotatercept in pulmonary arterial hypertension (PAH).
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Osimertinib plus chemo beat chemo alone in patients with advanced EGFR-mutated NSCLC who advanced on first-line osimertinib
Experts said the results of the COMPEL trial support continued treatment with osimertinib beyond progression in this patient population.
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Multidisciplinary panel highlights considerations for GLP-1 agonist use in OSA
Chitra Lal, MD, FCCP, discussed the current indications and coverage criteria for use of tirzepatide for treatment of OSA, as well as possible roles for other GLP-1 agonists.
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Nerandomilast opens the door for potential monotherapy, add-on therapy for pulmonary fibrosis
Positive results from the FIBRONEER trials of nerandomilast in IPF and PPF have sent the phosphodiesterase 4B inhibitor to the FDA for marketing approval. If approved, nerandomilast would be the first new antifibrotic agent for ILD in more than a decade.
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Prevention of COPD exacerbations with an eosinophilic endotype
With the recent US approval of the IL-5-directed monoclonal antibody mepolizumab as an add-on therapy for patients with COPD, the era of COPD biologics is undeniably here.
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Tezepelumab found to reduce oral corticosteroid use in severe asthma
The WAYFINDER study shows a clinically meaningful reduction in oral corticosteroid dosing, which may allow patients to get off steroids, said pulmonology expert Stephen T. Doyle, DO, MBA, FCCP.
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Varenicline found effective for nicotine vaping cessation in youth
Researcher A. Eden Evins, MD, said she was surprised by the ineffectiveness of behavioral therapy alone.
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Oseltamivir beats supportive care for patients hospitalized with seasonal influenza
Investigator Anthony Bai, MD, MSc, and infectious disease expert Christina Thornton, MD, PhD, discuss a large analysis that showed an in-hospital mortality rate of 3.5% for oseltamivir vs 4.9% for supportive care.
