News
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Varenicline sampling with minimal guidance may boost smoking cessation rates
According to the investigators, the medication sampling model may lower barriers to engagement and allow patients to consider cessation on their own terms.
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Short-course all-oral therapy appears effective, safe for resistant TB
Patrick PJ Phillips, PhD, said the noninferiority BEAT Tuberculosis trial showed a six-month treatment strategy could achieve outcomes similar to those of longer, standard regimens.
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Ensitrelvir cuts COVID-19 risk by two-thirds after household exposure
Paul E. Sax, MD, said postexposure prophylaxis may be a useful addition to vaccination, testing, and treatment, particularly in populations at high-risk of severe disease.
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Study evaluates amivantamab plus lazertinib for EGFR-mutant NSCLC with CNS metastases
With the combination now available, Mark Jeng, MD, PhD, revisits positive results from a recent study evaluating the strategy in this high-risk population.
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FDA warning on montelukast linked to prescription decline for asthma
Sami Hossri, MD, FCCP, said that while data show the warning prompted an immediate and sharp drop in new prescriptions, the shift in overall use was more modest.
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MARCH trial challenges routine use of mucoactive therapies in mechanically ventilated patients
Jesse Hall, MD, said the safety findings revealed “clinically significant events and tip the balance from ‘no benefit’ to ‘no benefit and likely harms.’”
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Study quantifies reduction in life expectancy for patients with COPD
Author Surya P. Bhatt, MD, MSPH, said whether newer therapies such as biologics or early-disease interventions can recover lost years remains unknown.
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Study links birth sites with lower levels of service to higher odds of resuscitation interventions
While factors such as socioeconomic status and remoteness were not associated with higher odds of interventions, lower-level birth sites were associated with higher odds of chest compressions.
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First-line zongertinib demonstrates durable responses in HER2-mutant NSCLC
Brett Bade, MD, and Katie Smith, MD, said the expansion of targeted therapies for lung cancer is an important advance, while noting that questions remain regarding the drug’s role in the first-line setting.
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Exercise-induced desaturation common among patients with COPD during early inpatient PR
Michele Vitacca, MD, and Mara Paneroni, PhD, said data show a disconnect between oxygen desaturation and symptom measures, highlighting the importance of objective physiological monitoring.
