Sepsis/Shock
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Precision immunotherapy for sepsis improves early organ dysfunction, study shows
Researcher Evangelos J. Giamarellos-Bourboulis, MD, PhD, said the conventional wisdom that patients start with hyperinflammation and progress to immunoparalysis is being called into question by the results.
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Updated sepsis guidelines balance rapid treatment initiation, antibiotic stewardship
In some cases, the new recommendations support treatment initiation before a patient reaches the hospital, while allowing flexibility in other cases to delay treatment until a sepsis diagnosis is confirmed.
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Study supports early TB therapy to reduce sepsis mortality in HIV
The ATLAS team of researchers said that because typical sepsis treatment does not target TB, clinicians should consider immediate TB treatment for people with HIV-related sepsis.
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Targeting capillary refill time identified as superior resuscitation strategy
Yuri Matusov, MD, said recent findings mark a significant step toward an individualized approach for managing septic shock.
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Latest data show peripheral vasopressors safer, quicker than central ports
Results from a recent analysis of the CLOVERS trial demonstrated a similar 90-day mortality rate with fewer complications for vasopressors compared with central venous catheter administration for the management of sepsis-induced hypotension.
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Experts preview ongoing work on guidelines for hemodynamic monitoring in septic shock
H. Bryant Nguyen, MD, MS, MBA, explored the case for retaining central venous pressure as a tool in assessing fluids in the treatment of sepsis.
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Shock resuscitation: Making the first 30 minutes count
Physician-educators share their approach to teaching shock recognition and management core skills to residents at the bedside.
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Study shows earlier vasopressin initiation for sepsis reduced in-hospital mortality
Critical care expert Natalie Achamallah, MD, FCCP, said OVISS data support guidelines that recommend earlier vasopressin as well as lower norepinephrine doses.
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Ketamine vs etomidate for intubation in patients who are critically ill
Commonly used for sedation for endotracheal intubation, these drugs are often selected for their favorable hemodynamic profiles.
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Procalcitonin levels may guide antibiotic duration in patients with suspected sepsis
Paul Dark, MD, PhD, said a 10% reduction in duration of antibiotic use shown in a recent study may seem small, but in the context of antibiotic stewardship, a 10% reduction is important.
