Sepsis/Shock
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Remote patient monitoring shows no benefit after serious infections, major trial finds
Researcher Sachin Yende, MD, MS, said the results challenge the assumption that remote monitoring alone improves postdischarge outcomes.
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Study supports 30 mL/kg or more of initial fluid for sepsis-induced hypoperfusion
Researchers also analyzed weight-based fluid resuscitation recommendations and found that, regardless of the approach, administration of 30 mL/kg of fluid was associated with reduced mortality.
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2026 Surviving Sepsis Campaign: Applying guidelines at the bedside
The guidelines distill available evidence into actionable recommendations to help clinicians navigate complex sepsis management processes and treat patients.
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Large trial finds no advantage for balanced fluids over saline in pediatric sepsis
Investigators Fran Balamuth, MD, PhD, MSCE, and Scott L. Weiss, MD, MSCE, said the results support the use of either therapy for initial sepsis resuscitation in children.
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Precision immunotherapy for sepsis improves early organ dysfunction, study shows
Researcher Evangelos J. Giamarellos-Bourboulis, MD, PhD, said the conventional wisdom that patients start with hyperinflammation and progress to immunoparalysis is being called into question by the results.
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Updated sepsis guidelines balance rapid treatment initiation, antibiotic stewardship
In some cases, the new recommendations support treatment initiation before a patient reaches the hospital, while allowing flexibility in other cases to delay treatment until a sepsis diagnosis is confirmed.
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Study supports early TB therapy to reduce sepsis mortality in HIV
The ATLAS team of researchers said that because typical sepsis treatment does not target TB, clinicians should consider immediate TB treatment for people with HIV-related sepsis.
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Targeting capillary refill time identified as superior resuscitation strategy
Yuri Matusov, MD, said recent findings mark a significant step toward an individualized approach for managing septic shock.
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Latest data show peripheral vasopressors safer, quicker than central ports
Results from a recent analysis of the CLOVERS trial demonstrated a similar 90-day mortality rate with fewer complications for vasopressors compared with central venous catheter administration for the management of sepsis-induced hypotension.
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Experts preview ongoing work on guidelines for hemodynamic monitoring in septic shock
H. Bryant Nguyen, MD, MS, MBA, explored the case for retaining central venous pressure as a tool in assessing fluids in the treatment of sepsis.
