News
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UK trial finds propofol remains preferred ICU sedation agent
The recent A2B trial found that neither dexmedetomidine nor clonidine are superior to propofol and may increase risks of agitation and bradycardia.
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As-needed albuterol-budesonide found to benefit mild asthma
Study author Craig LaForce, MD, and pulmonologist Kevin Fussell, MD, discuss findings from the BATURA trial and their clinical implications.
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Probiotics shortened fever duration in children with upper respiratory tract infections
Investigator Carlo Agostoni, MD, said the data show probiotic use was associated with a median reduction of fever by two days compared with placebo.
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COURSE trial shows importance of biomarker testing in COPD
While overall the trial was negative, Meilan King Han, MD, MS, and Sanjay Ramakrishnan, MBBS, PhD, said it demonstrated the promise of tezepelumab for patients with baseline blood eosinophil counts ≥ 150 cells/µL.
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Procalcitonin levels may guide antibiotic duration in patients with suspected sepsis
Paul Dark, MD, PhD, said a 10% reduction in duration of antibiotic use shown in a recent study may seem small, but in the context of antibiotic stewardship, a 10% reduction is important.
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Admilparant phase 2 results raise hopes for combination treatment in pulmonary fibrosis
Fernando Martinez, MD, FCCP, said he expects the treatment options for fibrotic lung disease will soon become more complex—in a good way—as more effective therapies become available.
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Dupilumab reverses airway inflammation, mucus hypersecretion in type 2 asthma
Lead author Mario Castro, MD, MPH, FCCP, said the VESTIGE trial is one of the first to show that we can reverse the disease process in asthma and substantially improve lung function.
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CMS decision positively impacts the future of home ventilation coverage
CMS recently released a decision on coverage for noninvasive ventilation devices for patients with COPD, a process that CHEST has been closely involved in.
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For the neuromuscular disease community, ventilation coverage victory doesn’t carry over
Patient advocate Spero Koulouras said he believes CMS home ventilation coverage criteria for patients with disorders such as ALS are still ambiguous enough that private insurers have interpreted them to deny and delay coverage.
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SWIFT studies show promise of IL-5-targeted twice-yearly option for severe asthma with an eosinophilic phenotype
Lauren E. Eggert, MD, said depemokimab could be a more convenient therapy choice for both patients and providers.
