Critical Care
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Intensive antiviral chemoprophylaxis in nursing homes reduces hospitalization
“The actionable message is not to aim for 100%; it is to reach the most residents in the first 48 hours,” said Viren Kaul, MD, FCCP.
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Remote patient monitoring shows no benefit after serious infections, major trial finds
Researcher Sachin Yende, MD, MS, said the results challenge the assumption that remote monitoring alone improves postdischarge outcomes.
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Sleep in the ICU: Why closed eyes do not mean rest
Unconsciousness is not synonymous with sleep. Available evidence increasingly supports treating sleep as an essential component of ICU care rather than a secondary comfort measure.
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Precision immunotherapy in sepsis: Beyond one size fits all
In an era of precision immunotherapy that targets specific pathways of the immune response based on measurable biomarkers, the development of rapid, multidimensional immune phenotyping tools is essential to translate precision sepsis care from concept to bedside.
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Study supports 30 mL/kg or more of initial fluid for sepsis-induced hypoperfusion
Researchers also analyzed weight-based fluid resuscitation recommendations and found that, regardless of the approach, administration of 30 mL/kg of fluid was associated with reduced mortality.
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2026 Surviving Sepsis Campaign: Applying guidelines at the bedside
The guidelines distill available evidence into actionable recommendations to help clinicians navigate complex sepsis management processes and treat patients.
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Rethinking vascular access in the ICU: The rise of peripheral vasopressors
Peripheral vasopressors are no longer an exception reserved for minutes before central access is obtained; they have become common practice nationwide.
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When everyone nods but no one understands
As critical care evolves, one of our greatest responsibilities is to ensure that patients and families have a clear and comprehensive understanding of their condition and care plan.
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MARCH trial challenges routine use of mucoactive therapies in mechanically ventilated patients
Jesse Hall, MD, said the safety findings revealed “clinically significant events and tip the balance from ‘no benefit’ to ‘no benefit and likely harms.’”
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Study links birth sites with lower levels of service to higher odds of resuscitation interventions
While factors such as socioeconomic status and remoteness were not associated with higher odds of interventions, lower-level birth sites were associated with higher odds of chest compressions.
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Impossible choices: Goal-concordant care in the ICU
Clinicians should approach discussions about goal-concordant care with curiosity, humility, and responsibility, for the benefit of both the patient and their family.
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Large trial finds no advantage for balanced fluids over saline in pediatric sepsis
Investigators Fran Balamuth, MD, PhD, MSCE, and Scott L. Weiss, MD, MSCE, said the results support the use of either therapy for initial sepsis resuscitation in children.
