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  • Setidegrasib demonstrates durable responses in KRAS G12D-mutant NSCLC

    Setidegrasib demonstrates durable responses in KRAS G12D-mutant NSCLC

    Coauthor Anup Kasi, MD, MPH, said the study represents an important step forward in the development of KRAS G12D-targeted therapies.


  • Study links isoflavone intake to reduced COPD morbidity

    Study links isoflavone intake to reduced COPD morbidity

    Mariah K. Jackson, PhD, RDN, LMNT, said that while the research does not establish causality, nutrition is generally a safe, well-tolerated, and cost-effective strategy to improve respiratory health.


  • New portable, accurate TB test may broaden access

    New portable, accurate TB test may broaden access

    International TB specialist Alfred A. Lardizabal, MD, said he believes the development will empower resource-limited communities by bringing TB diagnostic capacity closer.



  • Large trial finds no advantage for balanced fluids over saline in pediatric sepsis

    Large trial finds no advantage for balanced fluids over saline in pediatric sepsis

    Investigators Fran Balamuth, MD, PhD, MSCE, and Scott L. Weiss, MD, MSCE, said the results support the use of either therapy for initial sepsis resuscitation in children.


  • The evaluation and management of OSA in medically hospitalized patients

    The evaluation and management of OSA in medically hospitalized patients

    These recommendations will hopefully prompt institutions to develop protocols for screening, diagnosing, and potentially offering PAP therapy to this patient population.


  • Seeing the target, missing the risk? Radiation safety in advanced bronchoscopy

    Seeing the target, missing the risk? Radiation safety in advanced bronchoscopy

    While patient exposure receives most of the attention when it comes to radiation risk, careful consideration must be given to the proceduralists and staff who are in the room day after day.


  • Positive results from TETON-1 trial introduce potential new therapy for IPF

    Positive results from TETON-1 trial introduce potential new therapy for IPF

    Positive results from the TETON trials and expanding treatment options are encouraging for pulmonologists who are used to working with a limited toolkit for slowing disease progression in their patients with IPF.


  • Ventilatory management of immune checkpoint inhibitor pneumonitis

    Ventilatory management of immune checkpoint inhibitor pneumonitis

    As immune checkpoint inhibitor use continues to expand, prospective data on phenotype-guided management and extracorporeal membrane oxygenation selection criteria are urgently needed.



  • Honoring a legacy, empowering the future

    Honoring a legacy, empowering the future

    The John R. Addrizzo, MD, FCCP, Endowed Research Grant in Sarcoidosis, a transformative and permanent fund dedicated to advancing research in sarcoidosis, is not only a tribute to a beloved husband, father, grandfather, and physician but also a beacon for progress and discovery.


  • Top reads from the CHEST journal portfolio – July 2026

    Top reads from the CHEST journal portfolio – July 2026

    Read new research from the journal portfolio on antimicrobial treatment of mild MAC-PD, defining Meth-APAH, and liberal vs conservative fluid therapy in sepsis.